Step 1: Glycolysis
Glycolysis is the first step in cellular respiration, where glucose is converted into pyruvate. This process takes place in the cytosol of the cell and does not require oxygen. The steps involved in glycolysis are:- Glucose is converted into glucose-6-phosphate using the enzyme hexokinase.
- Glucose-6-phosphate is then converted into fructose-6-phosphate.
- Fructose-6-phosphate is converted into fructose-1,6-bisphosphate.
- Fructose-1,6-bisphosphate is then converted into two molecules of glyceraldehyde-3-phosphate.
- Glyceraldehyde-3-phosphate is converted into 1,3-bisphosphoglycerate.
- 1,3-Bisphosphoglycerate is converted into 3-phosphoglycerate.
- 3-Phosphoglycerate is converted into phosphoenolpyruvate.
- Phosphoenolpyruvate is converted into pyruvate.
Step 2: The Citric Acid Cycle (Krebs Cycle)
- Pyruvate is converted into acetyl-CoA in a reaction catalyzed by the enzyme pyruvate dehydrogenase.
- Acetyl-CoA is then converted into citrate.
- Citrate is converted into isocitrate.
- Isocitrate is converted into α-ketoglutarate.
- α-Ketoglutarate is converted into succinyl-CoA.
- Succinyl-CoA is converted into succinate.
- Succinate is converted into fumarate.
- Fumarate is converted into malate.
- Malate is converted into oxaloacetate.
Step 3: Oxidative Phosphorylation
Oxidative phosphorylation is the final step in cellular respiration, where the energy from the electron transport chain is used to produce ATP. This process takes place in the mitochondria and involves the transfer of electrons from high-energy electron carriers to oxygen, resulting in the production of a proton gradient. The steps involved in oxidative phosphorylation are:Electrons from NADH and FADH2 are passed through a series of electron carriers in the electron transport chain, resulting in the production of a proton gradient.
Step 4: ATP Synthesis
ATP synthesis is the final step in cellular respiration, where the energy from the proton gradient is used to produce ATP. This process involves the enzyme ATP synthase, which uses the energy from the proton gradient to drive the production of ATP from ADP and Pi. The steps involved in ATP synthesis are:Protons flow back across the inner mitochondrial membrane, driving the rotation of the stalk subunit of ATP synthase.
Comparing the Efficiency of Different Energy-Yielding Pathways
| Energy-yielding pathway | ATP/1 glucose molecule |
|---|---|
| Glycolysis | 2 ATP |
| Citric acid cycle | 1 ATP |
| Electron transport chain | 32-34 ATP |